查格雷斯河（西班牙语：Río Chagres西班牙语发音：[ˈtʃaɣɾes]），位于巴拿马中部，是巴拿马运河流域的最大河流。

The Chagres River (Spanish pronunciation: [ˈtʃaɣɾes]), in central Panama, is the largest river in the Panama Canal's watershed. The river is dammed twice, and the resulting reservoirs—Gatun Lake and Lake Alajuela—form an integral part of the canal and its water system. Although the river's natural course runs northwest into the Caribbean Sea, its waters also flow, via the canal's locks, into the Gulf of Panama to the south, entitling the Chagres to the unusual claim of drainage into two oceans.