赛克斯顿（Sikeston）是位于美国密苏里州斯科特县和新马德里县的一座城市，人口约1.7万（2000年）。

Sikeston /ˈsaɪkstən/ is a city located both in southern Scott County and northern New Madrid County, in the U.S. state of Missouri. It is situated just north of the "Missouri Bootheel", although many locals consider Sikeston a part of it. By way of Interstate 55, Interstate 57, and U.S. Route 60, Sikeston is close to the halfway point between St. Louis, Missouri and Memphis, Tennessee and three hours from Nashville, Tennessee. The city is named after John Sikes, who founded it in 1860. It is the principal city of the Sikeston Micropolitan Statistical Area, which consists of all of Scott County, and has a total population of 41,143.