转录阻抑物CTCF（又叫11-锌指蛋白或CCCTC-结合因子），是CTCF基因编码的转录因子，与绝缘子的活性相关。

CTCF蛋白在通过与H-19印记控制区域（imprinting control region，ICR）和分化甲基化区域1（differentially-methylated region-1，DMR1）和MAR3结合 抑制胰岛素样生长因子2基因的过程中起重要作用。 CTCF与靶顺序因子的结合可阻断增强子和启动子的相互作用。从而将增强子的活性限制在一定的功能区域。除了阻断增强子外，CTCF还可作为染色质屏障阻止异染色质的传播。

Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of chromatin architecture.