Caspase 8
（重定向自FLICE）
![](/Images/godic/202501/13/Protein_CASP8_PDB_1f9e4912.png")
![](/Images/godic/202501/13/PBB_GE_CASP8_213373_s_at_tn4912.png")
![](/Images/godic/202501/13/PBB_GE_CASP8_207686_s_at_tn4912.png")
![Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps](/Images/godic/202501/13/TNF_signaling4912.jpg")
Caspase-8 is a caspase protein, encoded by the CASP8 gene. It most likely acts upon caspase-3. CASP8 orthologs have been identified in numerous mammals for which complete genome data are available. These unique orthologs are also present in birds.