As a result, a double-stranded break on one of the chromosomes can be repaired by using the sister chromatid.

所以，一条染色体上的双链断裂可利用其姐妹染色单体进行修复。

Since homology-directed repair uses a sister chromatid as a template, this is a more reliable repair mechanism than non-homologous end joining because there's no loss of nucleotides.

由于同源介导修复是以姐妹染色单体为模板，这种修复机制比非同源末端连接更可靠，因为没有核苷酸丢失。