开普吉拉多（英语：Cape Girardeau，英语发音：/ˈkeɪpdʒɨˈrɑrdoʊ/，法语：Cap-Girardeau，[kap ʒiʁaʁdo]，常简称为开普"Cape"）是美国密苏里州开普吉拉多县的一个城市，西北距圣路易斯约115英里（185公里），南离孟菲斯约175英里（282公里）。在2010年美国人口普查中，开普吉拉多37,941人，是密苏里州第16大城市，也是密苏里州东南部最大城市。

Cape Girardeau (/ˈkeɪp dʒᵻˈrɑːrdoʊ/, French:Cap-Girardeau [kap ʒiʁaʁdo]; colloquially referred to as "Cape") is a city located in Cape Girardeau County, Missouri in the United States. It is located approximately 115 miles (185 km) southeast of St. Louis and 175 miles (282 km) north of Memphis. As of the 2010 U.S. Census, the city's population was 37,941, making it the 16th-largest city in Missouri, and the largest city in Southeast Missouri. An emerging college town, it is the home of Southeast Missouri State University.