美国联邦证人保护项目（英语：United States Federal Witness Protection Program）是由美国司法部管理、美国法警局具体执行的证人保护计划，在审判之前、期间或之后为受威胁的证人提供保护。

包括加利福尼亚州、纽约州与德克萨斯州在内的少数一些州因为有其自己的证人保护项目而没有参与到此联邦项目之中。联邦项目比这些由各州独立运行的项目提供了更为广泛的保护。

The United States Federal Witness Protection Program, also known as the Witness Security Program or WITSEC, is a witness protection program administered by the United States Department of Justice and operated by the United States Marshals Service that is designed to protect threatened witnesses before, during, and after a trial.