Wamsutter is a town in Sweetwater County, Wyoming, United States. The population was 451 at the 2010 census.

The original inhabitants of the area were the Shoshone and Ute tribes. Westerners did not really settle in the county until the coming of the railroad in the 1860s. Originally, the town was known as Washakie. Confusion with nearby Fort Washakie prompted an 1884 name change to Wamsutter, after a Union Pacific bridge engineer.