Alpha-mannosidosis
![Electron micrograph of a vacuolated lymphocyte. Electron micrograph of a vacuolated lymphocyte from a mannosidosis patient (A) as compared to a lymphocyte from a normal control (B).](/Images/godic/202412/20/Alpha-mannosidosis_electron_micrograph0129.JPEG")
![Facial features in alpha-mannosidosis. A. Twins aged 18 Months. Note enlarged head, short neck, rounded eyebrows, saddle nose, and prominent forehead. B. Same twins aged 8 years. Note slight muscular atrophy of the hands. C. Boy, aged 27. Note: Hearing aid.](/Images/godic/202412/20/Alpha-mannosidosis0129.JPEG")
![Alpha-mannosidosis has an autosomal recessive pattern of inheritance.](/Images/godic/202412/20/Autorecessive.svg0129.png")
Alpha-mannosidosis is a lysosomal storage disorder caused by deficient activity of the enzyme alpha-D-mannosidase. In humans it is known to be caused by an autosomal recessive genetic mutation. In livestock it is caused by chronic poisoning with swainsonine from locoweed.