蒂萨河（匈牙利语：Tisza、罗马尼亚语、斯洛伐克语：Tisa；乌克兰语：Тиса；塞尔维亚语：Тиса/Tisa）全长1,358公里，流域面积157,183平方公里，为多瑙河最大支流。

起源于乌克兰喀尔巴阡山脉，流经罗马尼亚、斯洛伐克、匈牙利和塞尔维亚，最后于伏伊伏丁那导入多瑙河。

The Tisza or Tisa is one of the main rivers of Central Europe. Once, it was called "The most Hungarian river" because it flowed entirely within Hungary. Today, it crosses several national borders.

The Tisza begins near Rakhiv in Ukraine, at the confluence of the White Tisa and Black Tisa (the former springs in the Chornohora mountains; the latter in the Gorgany range). From there, the Tisza flows west, roughly following Ukraine's borders with Romania, then Hungary, and finally Serbia. It enters Hungary at Tiszabecs. It traverses Hungary from north to south. A few kilometers south of the Hungarian city of Szeged, it enters Serbia. Finally, it joins the Danube near the village of Novi Slankamen in Vojvodina, Serbia.