萨斯奎哈纳河（Susquehanna River）起源于美国纽约州Cooperstown，纵贯宾夕法尼亚州，在马里兰州北部流入切萨皮克湾。全长715公里，是美国东岸最长的河流，也是全美第十六长河流。

美国历史上最严重的核电厂意外三浬岛事件位于哈里斯堡河段。

The Susquehanna River (/ˌsʌskwəˈhænə/; Lenape: Siskëwahane) is a river located in the northeastern United States. At 464 miles (747 km) long, it is the longest river on the American east coast that drains into the Atlantic Ocean. With its watershed, it is the 16th-largest river in the United States, and the longest river in the continental United States without commercial boat traffic today. In the Canal Era, navigation improvements were made to enhance the river for barge shipping of bulk goods by water transport on the Pennsylvania Canal; competition from faster transport via the railroad industry resulted in reducing the maintenance on the river.