Secretary of State or State Secretary is a commonly used title for a senior or mid-level post in governments around the world. The role varies between countries, and in some cases there are multiple Secretaries of State in the Government.

In many countries, a Secretary of State is a mid-level post. It is usually a politically appointed position, although in some countries, such as Germany and Sweden, it can be filled by a member of the executive bureaucracy (civil service) as a political appointment. In the Holy See, there is one Secretary of State, who coordinates all the departments of the Roman Curia (that is, equivalent to a Prime Minister). In the United Kingdom a Secretary of State is a member of the Cabinet appointed by the Queen on the advice of the Prime Minister (that is, equivalent to a Minister). In the federal government of the United States, there is one Secretary of State, the most senior political appointee responsible for foreign policy (that is, equivalent to a Foreign Minister).