As a result, a double-stranded break on one of the chromosomes can be repaired by using the sister chromatid.

所以，一条染色体上的双链断裂可利用其姐妹染色单体进行修复。

That donor DNA will act like a sister chromatid as a reference to recreate the lost genetic information.

该供体DNA会像姐妹染色单体一样，作为重建遗传信息的参考。

So now End 1 is placed near a similar nucleotide sequence, called the homologous sequence, because it's found in the same spot on the homologous sister chromatid.

现在End 1位于一段相似核苷酸序列附近；这段序列被称为同源序列，位于同源姐妹染色单体上的相同位点。

Since homology-directed repair uses a sister chromatid as a template, this is a more reliable repair mechanism than non-homologous end joining because there's no loss of nucleotides.

由于同源介导修复是以姐妹染色单体为模板，这种修复机制比非同源末端连接更可靠，因为没有核苷酸丢失。