Securin
![Figure 1: Securin and separase are widely conserved](/Images/godic/202502/10/Securin-separase_conserved5147.png")
![Figure 2: Five identified phosphorylation sites on securin](/Images/godic/202502/10/Securin_phosphorylation_sites25147.jpg")
![Figure 3: Network diagram with feedback loops to generate switch-like activation of anaphase](/Images/godic/202502/10/Network_picture5147.png")
![Figure 4: Potential network diagram involving securin to generate switch-like activation of anaphase](/Images/godic/202502/10/Complete_network5147.jpg")
Securin is a protein involved in control of the metaphase-anaphase transition and anaphase onset. Following bi-orientation of chromosome pairs and inactivation of the spindle checkpoint system, the underlying regulatory system, which includes securin, produces an abrupt stimulus that induces highly synchronous chromosome separation in anaphase.