腺苷脱氨酶（英语：Adenosine deaminase）的是一种参与嘌呤代谢作用的酶。它是用作拆解食物组织中的核酸中的腺苷。

腺苷脱氨酶对腺苷进行不可逆转的脱氨作用,转化腺苷为相关的核苷肌苷,移除氨基酸组。

Adenosine Deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.

Its primary function in humans is the development and maintenance of the immune system. However, the full physiological role of ADA is not yet completely understood.