Santa Rosa de Copán (Spanish pronunciation: [ˈsanta ˈrosa ðe koˈpan]) is the departmental capital of the Honduran department of Copán. It is approximately 1,150 metres (3,773 ft) above mean sea level.

Santa Rosa de Copán, Honduras, is the largest and most important city in western Honduras with a population of 42,803. Santa Rosa is the governmental hub of the department of Copán. The city is connected through the International Highway of the West (CA-4) with San Pedro Sula to the North and with the borders of El Salvador at El Poy and Guatemala at Agua Caliente to the west. Santa Rosa has a subtropical climate with temperatures ranging from 25 °C (77 °F) to 29 °C (84 °F) in the summer (March–June), and from 13 °C (55 °F) to 15 °C (59 °F) in the winter (December–February).