Objective: To study the preliminary clinical application of serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen(ICTP) detection in patients with rheumatoid arthritis(RA).
研究I型胶原吡啶交联终肽(ICTP)检测在类风湿关节炎(RA)中的初步应用。
Pyridinoline
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Pyridinoline
![](/Images/godic/202502/05/Structure_of_Pyridinoline1322.png")
Pyridinoline, also known as Hydroxylysylpyridinoline, is a fluorescent cross-linking compound of collagen fibers. Crosslinks in collagen and elastin are derived from lysyl and hydroxylysyl residues, a process catalyzed by lysyl oxidase. Fujimoto and colleagues first described the isolation and characterization of a fluorescent material in bovine Achilles tendon collagen and termed it pyridinoline. It is reported to be present in collagen of bone and cartilage, but is absent in collagen of skin. It is not present in newly synthesized collagen and is formed from aldimine cross-links during maturation of collagen fibers.
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