Pantodonta is an extinct suborder (or, according to some, an order) of eutherian mammals. These herbivorous mammals were one of the first groups of large mammals to evolve after the end of the Cretaceous.

Pantodonta include some of the largest mammals of their time, but were a diversified group, with some primitive members weighing less than 10 kg (22 lb) and the largest more than 500 kg (1,100 lb).