马托格罗索州（葡萄牙语：Mato Grosso）是巴西西部的一个州，首府库亚巴，人口2,856,999人。

Mato Grosso (Portuguese pronunciation: [ˈmatu ˈɡɾosu] – lit. "Thick Bushes") is one of the states of Brazil, the third largest by area, located in the western part of the country.

Neighboring states are (from west clockwise) Rondônia, Amazonas, Pará, Tocantins, Goiás and Mato Grosso do Sul. It also borders Bolivia to the southwest. A state with a flat landscape, alternating great chapadas and plain areas, Mato Grosso presents three different ecosystems: Cerrado, Pantanal and the Amazon Rainforest. The vegetation of the open pasture covers 40% of the state, and the Chapada dos Guimarães National Park, with its caves, grottos, tracks and waterfalls, is one of its great tourist attractions. In the north is the Amazonian forest, with a biodiversity originally covering half of the state, currently largely devastated for logging, agricultural purposes and pastures. The Xingu National Park and the Araguaia River are in Mato Grosso. Further south, the Pantanal, the world's largest wetland, is the habitat for almost a thousand species of animals, with many aquatic birds.