马格达莱纳河（西班牙语：Río Magdalena）是哥伦比亚境内的主要河流。它得名于圣经人物抹大拉的马里亚（Mary Magdalene）。

马格达莱纳河发源于哥伦比亚乌伊拉省境内的安第斯山脉，向北流淌，最终在巴兰基亚注入加勒比海，全长约1,540公里，流域面积26万平方公里。

沿河主要城市有：翁达、博亚卡港、巴兰卡韦梅哈、巴兰基亚等。

The Magdalena River (Spanish:Río Magdalena, Spanish pronunciation: [ˈri.o maɣðaˈlena]; Less commonly Rio Grande de la Magdalena) is the principal river of Colombia, flowing northward about 1,528 kilometres (949 mi) through the western half of the country. It takes its name from the biblical figure Mary Magdalene. It is navigable through much of its lower reaches, in spite of the shifting sand bars at the mouth of its delta, as far as Honda, at the downstream base of its rapids. It flows through the Magdalena River Valley.