卡斯科奎姆河（Kuskokwim River）是美国阿拉斯加州南部的一条河流。在费尔班克斯西南偏西约320公里处的卡斯科奎姆山发源，向西南流淌，最终在卡斯科奎姆湾注入白令海。全长1165公里。按河口平均流量来算，是美国第九大河流。

The Kuskokwim River or Kusko River (Kusquqvak in Yup'ik) is a river, 702 miles (1,130 km) long, in Southwest Alaska in the United States. It is the ninth largest river in the United States by average discharge volume at its mouth and seventeenth largest by basin drainage area.