In enzymology, a homoisocitrate dehydrogenase (EC1.1.1.87) is an enzyme that catalyzes the chemical reaction

Thus, the two substrates of this enzyme are (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate and NAD, whereas its 4 products are 2-oxoadipate, CO₂, NADH, and H.