Hantzsch吡啶合成（Hantzsch pyridine synthesis），又称Hantzsch二氢吡啶合成（Hantzsch dihydropyridine synthesis）

醛（如甲醛）、两分子β-酮酯（如三乙）和含氮化合物（如乙酸铵或氨）之间的多组分反应。 反应最初产物是二氢吡啶类，二氢吡啶接下来再被氧化，可得吡啶衍生物。氧化反应的推动力是有芳香性的吡啶环的生成。

1,4-二氢吡啶二羧酸酯也称 Hantzsch 化合物，在医药上可用作钙信道阻滞剂。例子有硝苯地平、氨氯地平和尼莫地平等。

The Hantzsch pyridine synthesis or Hantzsch dihydropyridine synthesis is a multi-component organic reaction between an aldehyde such as formaldehyde, 2 equivalents of a β-keto ester such as ethyl acetoacetate and a nitrogen donor such as ammonium acetate or ammonia. The initial reaction product is a dihydropyridine which can be oxidized in a subsequent step to a pyridine. The driving force for this second reaction step is aromatization. This reaction was reported in 1881 by Arthur Rudolf Hantzsch.