Guánica (Spanish pronunciation: [ˈɡwanika]) is a town and municipality in southern Puerto Rico, bordering the Caribbean Sea, south of Sabana Grande, east of Lajas, and west of Yauco. It is part of the Yauco Metropolitan Statistical Area.

The town of Guánica, also known as Pueblo de Guánica, is the principal town of the municipality. The town's population in 2000 was 9,247 people among 3,808 housing units over a land area of 2.49 square miles (6.45 km). The town is located on a deeply indented harbor of the same name. The harbor resembles a tropical fjord, narrow and bordered by rugged hills, barely a quarter-mile wide, but about two miles (3 km) from mouth to the town. The town is about 100 miles (160 km) and over two hours driving distance from San Juan, the capital city of the island, and about 20 miles (30 km) west of Ponce, another principal city of the island.