In type 1 diabetes, there is a genetic abnormality causes a loss of self-tolerance among T cells that specifically target the beta cell antigens.

1型糖尿病患者有一类基因异常，造成攻击β细胞抗原的T细胞失去了自身耐受的能力。

Klinefelter Syndrome is a genetic abnormality in which at least one additional x chromosome is inherited by an XY male as a result of impaired meiosis in the parental gametes.

Klinefelter综合征是一种基因异常病；本该以XY为基因型的男性多得到一条X染色体，从而患病，这通常是亲代配子的减数分裂异常的结果。

And these genetic abnormalities are the reason or these tumors in the end, and there, and and we have basically been able to comprehensively study that.

这些基因异常是最终导致这些肿瘤的原因，在那里，我们基本上可以全面研究。

They would need to have a close enough human leukocyte antigen or HLA match to maximise the chances the transplant would work - as well as the rare genetic abnormality conferring HIV resistance.

他们需要有足够接近的人类白细胞抗原或 HLA 匹配，以最大限度地提高移植成功的机会——以及罕见的遗传异常导致 HIV 耐药。