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词汇 galactokinase
分类 英语词汇 英语翻译词典
释义

galactokinase /ɡə,læktəu'kaineis/

英汉-汉英词典
n. 半乳糖激酶
词组 | 习惯用语
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  • intergalactic adj. 银河间的
  • glockenspiel n. 钟琴；钟乐器
  • extragalactic adj. (位于或来自于)银河系外的
galactokinase [生化] 半乳糖激酶

网络短语:
galactokinase deficiency 半乳糖激酶缺乏症
中文百科

半乳糖激酶

Figura 2. Estructura cristalina del sitio activo de la galactoquinasa del Lactococcus lactis.[13] La galactosa se muestra en verde, el fosfato en naranja y los residuos responsables de la unión del azúcar a la enzina en magenta: Arg-36, Glu-42, Asp-45, Asp-183 y Tyr-233. Arg-36 y Asp-183 de la galactoquinasa del Lactococcus lactis son análogos a los residuos Arg-37 y Asp-186 de la galactoquinasa humana.(From PDB 1PIE )
Figura 3. Mecanismo de la galactoquinasa.[11] El residuo aspartato es estabilizado en su forma aniónica por un residuo arginina cercano.
Figura 4. Ruta de Leloir. Metabolitos: (1) galactosa, (2) galactosa-1-fosfato, (3) UDP-glucosa, (4) UDP-galactosa, (5) glucosa-1-fostato, (6) glucosa-6-fosfato. Enzimas: (GK) galactoquinasa, (GALT) galactosa-1-fosfato uridiltransferasa, (UDE) UDP-galactosa 4-epimerasa, (PGM) fosfoglucomutasa.

半乳糖激酶（英语：Galactokinase）是一种催化α-D-半乳糖磷酸化为半乳糖-1-磷酸的磷酸转移酶，在此过程中消耗一分子ATP。半乳糖激酶催化Leloir途径（有机体中将α-D-半乳糖转化为葡萄糖-1-磷酸的代谢途径）的第二步反应，最早在哺乳动物的肝脏中发现, 后来在酵母、古菌、植物和人类中都有发现。

英语百科

Galactokinase 半乳糖激酶

The likely galactokinase mechanism.[9] The aspartate residue is stabilized in its anionic form by a nearby arginine residue.
Crystal structure of galactokinase active site from Lactococcus lactis. [11] Galactokinase is shown in green, phosphate in orange, and the residues responsible for binding the sugar ligand are shown in magenta: Arg-36, Glu-42, Asp-45, Asp-183, and Tyr-233. Arg-36 and Asp-183 of Lactococcus lactis galactokinase are analogous to Arg-37 and Asp-186 in human galactokinase. (From PDB: 1PIE​)
Figura 4. Ruta de Leloir. Metabolitos: (1) galactosa, (2) galactosa-1-fosfato, (3) UDP-glucosa, (4) UDP-galactosa, (5) glucosa-1-fostato, (6) glucosa-6-fosfato. Enzimas: (GK) galactoquinasa, (GALT) galactosa-1-fosfato uridiltransferasa, (UDE) UDP-galactosa 4-epimerasa, (PGM) fosfoglucomutasa.

Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP. Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of β-D-galactose to glucose 1-phosphate. First isolated from mammalian liver, galactokinase has been studied extensively in yeast, archaea, plants, and humans.
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